C j paddon, p j westfall, d j pitera, k benjamin, k fisher, d mcphee, m d leavell, a tai, a main, d eng, d r polichuk, k h teoh, d w reed, t treynor, j lenihan, m fleck, s bajad, g dang, d dengrove, d diola, g dorin, k w ellens, s fickes, j galazzo, s p gaucher, t geistlinger, r henry, m hepp, t. Improvement in the yield of artemisinin, a novel and potent anti malarial compound, through conventional breeding, invitro culture, hairy. Highlevel semisynthetic production of the potent antimalarial. The antimalarial drug artemisinin is a natural product produced by. Frontiers approaches and recent developments for the. A stable source of affordable artemisinin is required. Nature 20412 highlevel semisynthetic production of the potent antimalarial artemisinin. Altmetric highlevel semisynthetic production of the.
Highlevel semisynthetic production of the potent antimalarial artemisinin. Entry of the antimalarial drug precursor semisynthetic artemisinin into industrial production is the first major milestone for the application of synthetic biology. Paddon cj1, westfall pj, pitera dj, benjamin k, fisher k. Highlevel semi synthetic production of the potent antimalarial artemisinin on publons. This will revolutionize the treatment and control of malaria in third world countries.
Increasing the strength and production of artemisinin and its. Stable production of the antimalarial drug artemisinin in. Cellular engineering for enhanced production of potent antimalarial. However, the supply of plantderived artemisinin is unstable, resulting in shortages and price fluctuations, complicating production planning by act manufacturers. Furthermore, we have developed a practical, efficient and scalable chemical process for the conversion of artemisinic acid to artemisinin using a. Pdf highlevel semisynthetic production of the potent. Pdf highlevel semisynthetic production of the potent antimalarial. Artemisinin is a sesquiterpene endoperoxide with potent antimalarial properties, produced by the plant artemisia annua.
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